Diosmetin (3',5,7-trihydroxy-4'-methoxyflavone) is a naturally occurring O-methylated flavone found in citrus peels, oregano, and the aerial parts of various medicinal plants. It is the aglycone form of diosmin, produced through acid hydrolysis or direct extraction and chromatographic purification.
Diosmetin demonstrates notable anti-inflammatory, antioxidant, vasoprotective, and anticancer properties in preclinical studies. It modulates NF-kB signaling and inhibits key inflammatory mediators. Commercially, diosmetin is used as a pharmaceutical intermediate, in vascular health supplement formulations, and as a research compound in flavonoid biology.
