Diosmin is a naturally occurring flavone glycoside primarily found in citrus fruit peels, particularly from Citrus sinensis and Citrus aurantium. Commercial production involves extraction from citrus waste or semi-synthesis from hesperidin through oxidation.
Diosmin is one of the most clinically validated venoactive flavonoids, with extensive evidence supporting its use in chronic venous insufficiency (CVI), hemorrhoids, and lymphedema. It enhances venous tone, reduces capillary permeability, and improves lymphatic drainage. Diosmin is commercially used in pharmaceutical vein-care preparations, vascular health supplements, and micronized flavonoid fractions.
