Vitamin B5 D-Calcium Pantothenate and Pantothenic acid

What is Pantothenic acid?

Pantothenic acid, also known as vitamin B5, is a water-soluble B vitamin. Pantothenic acid is an essential nutrient. Animals require pantothenic acid in order to synthesize coenzyme-A (CoA), as well as to synthesize and metabolize proteins, carbohydrates, and fats. The calcium salt of Pantothenic acid is called D-Calcium Pantothenate. It can be used as food additives, feed additives and pharmaceutical ingredients. As a supplier of D-calcium pantothenate, we supply high quality D-calcium pantothenate from China manufacturers.

Another name for pantothenic acid: VB5; pantothenic acid, pantothenate. Vitamin b5 scientific name:Pantothenic acid

pantothenic acid structure: 

Good sources of vitamin b5 Pantothenic acid in food

Foods high in pantothenic acid include mushrooms, cheese, fish, avocados, eggs, lean pork, beef, veal, chicken, sunflower seeds, salmon, corn, cauliflower and sweet potatoes. Whole grains are major sources of pantothenic acid, but processing and refining grains may result in a 35% to 75% loss. Freezing and canning of foods result in similar losses

Coenzyme form of vitamin B5 pantothenic acid in body

Pantothenic acid is a metabolically active component of coenzyme A (CoA) essential for the metabolism of carbohydrates, fats, and proteins and for acyl carrier protein (ACP), a component of FA synthesis. Animals require pantothenic acid in order to synthesize Coenzyme A.

D-Calcium pantothenate VS Pantothenic acid

D-calcium pantothenate is a synthetic vitamin B-5 supplement manufactured from pantothenic acid. It is a more stable form of the vitamin b5 and is often used as a source of the vitamin B5 in multivitamin supplements. Calcium pantothenate, as it is a salt, it is more stable than pantothenic acid and it is often used in dietary supplements.

Pantothenic acid is a very unstable chemical that is easily degraded by exposure to light, heat, or acids. To stabilize pantothenic acid to make sure it won’t break down in a supplement,  manufacturers combine it with calcium to make D-calcium pantothenate.D-calcium pantothenate is easily break down to pantothenic acid that the body can readily use.

There are several different chemicals identified as vitamin B5. The form of vitamin B5 that is active in living organisms is D-pantothenic acid. It’s the only form of vitamin B5 that actually serves any function in living cells.

Panthenol

Panthenol, also called pantothenol, is a stable alcohol analog of pantothenic acid (vitamin B5), and is thus a provitamin of B5. It is often used as a source of the vitamin in multivitamin supplements.

It also called D-Panthenol. It plays a key role in the human intermediary metabolism. Deficiency of Vitamin B5 can result in many dermatological disorders. D-Panthenol is applied in pharmaceutical industry and almost all types of cosmetic preparations. It cares hair, skin and nails.

What is vitamin B5 D-calcium pantothenate?

D-calcium pantothenate, also call Calcium D-pantothenate is a synthetic vitamin B-5 supplement manufactured from pantothenic acid. It is a more stable form of the vitamin b5 and is often used as a source of the vitamin B5 in multivitamin supplements.

Properties

D-calcium pantothenate is a white powder, no smelly odor, tastes a little bitter, has hydroscopic property. Its aqueous solution shows neutrality or slightly alkaline, easy to dissolve in water, slightly solvable in ethanol, almost can not dissolve in chloroform or aether.

Chemical formula

C18H32CaN2O10

Chemical structure

Molecular weight

476.53

CAS No.

137-08-6

D-calcium pantothenate solubility

Readily soluble in water, soluble in glycerol, somewhat soluble in ethanol and virtually insoluble in ether and chloroform.

vitamin B5 D-calcium pantothenate manufacturing process

The manufacturing process of D-calcium pantothenate consists of three steps of synthesis of β-alanine (intermediate), DL-pantolactone (intermediate) and D-calcium pantothenate. There are two commonly used synthetic processes, one is DL. – Reaction of pantolactone with β-alanine to generate calcium DL-pantothenate, then resolved to calcium D-pantothenate; the other is the resolution of DL-pantolactone by chemical or biological methods. D-pantolactone reacts with β-alanine to produce calcium D-pantothenate. Among them, cyanide-containing waste water is more contaminated during the production of DL-pantolactone.

Vitamin B5 D-calcium pantothenate Function

Vitamin B5 D-calcium pantothenate function in the body

D-calcium pantothenate participates in the manufacturing of energy in the body and can control the metabolism of fat. It is an essential nutrient for the brain and nerves. It can help with the secretion of anti-stress hormones (steroids) in the body. It can keep skin and hair healthy.

D-calcium pantothenate helps cell formation, maintains normal development and development of the central nervous system; it is essential for maintaining the normal function of the adrenal glands; is essential for the conversion of fats and carbohydrates to energy; in the synthesis of antibodies, it helps human use of para-aminobenzoic acid and essential choline.

D-calcium pantothenate can strengthen the normal skin hydration function, improve dryness, roughness, desquamation, relieve itching, and treat various skin diseases (such as atopic dermatitis). Phosphorus, psoriasis, and contact dermatitis) related erythema effects.

Strengthen the skin barrier function: D-calcium pantothenate can promote normal skin keratinization and improve the skin’s tolerance to surfactants. Reduces discomfort caused by sensitive ingredients in cosmetics like burning, tingling, itching.

What does Vitamin b5 do?

Vitamin B5, also called pantothenic acid, is one of the most important vitamins for human life. It’s necessary for making blood cells, and it helps you convert the food you eat into energy. Vitamin B5 is one of eight B vitamins. All B vitamins help you convert the protein, carbohydrates, and fats you eat into energy.

Vitamin B5 Pantothenic acid absorption

When found in foods, most pantothenic acid is in the form of coenzyme A or bound to acyl carrier protein (ACP). For the intestinal cells to absorb this vitamin, it must be converted into free pantothenic acid. Within the lumen of the intestine, coenzyme A and ACP are hydrolyzed into 4′-phosphopantetheine. The 4′-phosphopantetheine is then dephosphorylated into pantetheine. Pantetheinase, an intestinal enzyme, then hydrolyzes pantetheine into free pantothenic acid.

Free pantothenic acid is absorbed into intestinal cells via a saturable, sodium-dependent active transport system.At high levels of intake, when this mechanism is saturated, some pantothenic acid may also be absorbed via passive diffusion. As intake increases 10-fold, however, absorption rate decreases to 10%.

Reference: https://en.wikipedia.org/wiki/Pantothenic_acid

Vitamin B5 Pantothenic acid metabolism

Pantothenates or alcohols, etc., are absorbed in the intestine and may be permeable to the small intestine. Pantothenic acid is part of the composition of coenzyme A. In tissues, pantothenic acid converts to co-enzyme A. Therefore, pantothenic acid is involved in fatty acid synthesis of steroids. It participates in the oxidation of pyruvate, alpha-ketoglutaric acid and fatty acids, and is also involved in the synthesis of fatty acids and steroids. Pantothenic acid acts on the adrenal glands, digestive tract, nerves and skin in the body.

Health Benefits of vitamin B5

D-Calcium pantothenate is used for prevention and treatment of D-pantothenic acid deficiency (e.g. by means of multivitamins or B-complex preparations). It is practical for preventing pantothenic acid deficiency as well as meeting particular nutritional requirements.

Deficiency of D-calcium pantothenate vitamin B5

In Humans

The deficiency of D-calcium pantothenate in humans has the following symptoms:

  • Growth stops, body weight decreases, and sudden death occurs.
  • Skin and hair disorders: hair fall
  • Neurological disorders.
  • Abnormal digestive organs, liver dysfunction.
  • Affecting antibody formation.

In Animals

In animal studies, the deficiency of pantothenic acid causes fetal reabsorption, abnormalities, stillbirth, corneal vascular lesions, bone lesions and so on.

The deficiency of D- calcium pantothenate in animals has the following symptoms:

The deficiency in pigs:

  • There are geese walking on the hind legs, and acne dermatitis is present at the tip of the nose and the eyes.
  • The hair becomes bald after it first loses color, and skin ulceration may occur when it deteriorates.
  • Degeneration of the nervous system causes paralysis.
  • Blood exudative rhinitis causes bronchopneumonia, bowel swelling, atrophy, and ulcers.
  • The liver is degraded due to fatty liver.
  • Kidneys have hemorrhagic necrosis.

Vitamin B5 D-calcium pantothenate Uses

Calcium D-pantothenate is mainly used as feed additives, food additives and pharmaceutical ingredients. Around 60% in global market are used in feed, 15% for veterinary drugs, 10% for pharmaceuticals, and 15% in food.

D- calcium pantothenate is often used in combination with other B vitamins in vitamin B complex formulations. Vitamin B complex generally includes vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B3 (niacin/niacinamide), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), and folic acid.

In food

D-calcium pantothenate can be used to a number of food products, e.g. products for babies and small children, food products like energy drinks for athletes, low-calorie and calorie-reduced foods, vitamin-fortified juices, etc. We supply high quality D-calcium pantothenate in the dietary supplement, food, beverage and infant nutrition industries to suit customer needs.

Dietary daily recommendations

Age group Age Adequate intake
Infants 0–6 months 1.7 mg
Infants 7–12 months 1.8 mg
Children 1–3 years 2 mg
Children 4–8 years 3 mg
Children 9–13 years 4 mg
Adult men and women 14+ years 5 mg
Pregnant women (vs. 5) 6 mg
Breastfeeding women (vs. 5) 7 mg

In feed

Calcium D-pantothenate is a vitamin drug in the feed industry. It is a component of Coenzyme A that regulates the metabolism of proteins, carbohydrates, and fats, maintains skin and mucous membranes, improves the color of hair (or feathers), and prevents the occurrence of diseases. It is essential for the growth, development of poultry, livestock and fishes and their fat synthesis and decomposition.

The dosage in feed additives

Piglets: 10 to 15 mg/kg
Growing and finishing pigs: 10 to 15 mg/kg
Egg chickens: 10 to 15 mg/kg
Breeding layer: 10 to 15 mg/kg
Laying hens: 20 to 25 mg/kg
Broiler: 20 to 25 mg/kg
Fish: 20 to 50 mg/kg

In cosmetics

D-calcium pantothenate can improve hair growth and pigmentation and protects the skin. it can be used in cosmetics products such as in hair care products, sun care products, shaving lotions and baby care products.

Vitamin B5 D-calcium pantothenate Side effects

Pantothenic acid toxicity symptoms

Pantothenic acid is not known to be toxic in humans. The only adverse effect noted was diarrhea resulting from very high intakes of 10 to 20 g/day of calcium D-pantothenate.

Vitamin B5 D-calcium pantothenate market

D-calcium pantothenate manufacturers and price trend in 2017

China is the big food and feed grade Calcium pantothenate manufacturers and export country in the world. China manufactures’ market takes around 60%.

 

The calcium pantothenate products (calcium D-pantothenate and D-panthenol, vitamin B5 and pro-B5) are mainly used in the fields of feed, food and pharmaceutical industry. They are necessary for animal growth, promote the utilization of nutrients, promote the synthesis and decomposition of fatty acids, etc. , It is an important additive in animal feed.

D-Calcium pantothenate is mainly monopolized by oligopolists in China. In 2016, the global vitamin B5 production companies mainly include Yifan, Xinfa, Huachen, BASF, and DSM. The global demand is about 19,200 tons, and the China market demand is about 3,350 tons. The global production capacity is about 25,000 tons, China accounts for more than 60%, China’s calcium pantothenate exports amounted to about 12,700 tons in 2015.

Environmental Protection Supervisor Suddenly Overweights in Shandong and that makes Pantothenic Calcium Prices Come to Historical Highs in 2017.

Due to the difficulty in handling cyanide-containing waste water during the production of calcium pantothenate, environmental protection pressures are high for manufacturers. At the same time, the number and production capacity of highly polluting bulk drug manufacturers in Shandong Province ranks in the forefront in the country. Frequent accidents are the main reasons that environmental protection inspectors are concerned about.

In April 2017, two factories in Shandong province suspended production due to environmental protection verification for one month. In June 2017, due to chemical plant explosion accidents, Shandong province carried out safety rectification across the province and stopped production again. That’s drive the price of D-calcium pantothenate to a record high position of 750 yuan/kg.

In August-September 2017, the fourth batch of Central Environmental Protection Inspectors visited Shandong and Zhejiang. Two factories ceased production and restricted production. The “2+26” atmospheric special rectification plan started in September covered Shandong and Hebei again. In key chemical cities, Shandong Province plans to carry out a five-year chemical industry safety production transformation and upgrading project after the chemical plant explosion in June. It is to conduct comprehensive chemical industry inspections and strict law enforcement from June to the end of 2017.

It is therefore expected that two factories in Shandong will continue to slow their release rate. With regard to new capacity of Brother will use the self-developed bio-enzyme dismantling process for the first time. Production line debugging will take some time. It is expected that the fourth quarter of 2017 will be completed. The release rate of new calcium pantothenate production capacity is expected to be reasonable. It is expected that the release of production capacity will not exceed 2,000 tons per annum in 2017, ie the output in the fourth quarter of 2017 is not expected to exceed 500 tons. The process of resuming production of two factories in Shandong is still limited, and the pattern of calcium pantothenate supply shortage is unlikely to be significant during the year.

Today’s price

Updated on 2018/05/26: Now the price for feed grade is around RMB68/kg, the price in January was around RMB360/kg, it decreased more than 80%.

Where to buy D-calcium pantothenate?

You can buy food or feed grade D-calcium pantothenate from us, Specification complies with BP/USP/EP/JP/FCC standard.

We’re committed to the quality and safety of our ingredients. We know that our customers expect us to use only the highest quality food additives & ingredients with better price, and we do everything we can to satisfy those expectations.

Usage: feed additives, food additives

Specification: BP/USP/EP/JP/FCC
Packing: 25kg / carton
Storage: Store in a cool and dry place
Validity: Shelf life of three years.

If you have any other questions, please email us through: info@foodsweeteners.com