Folate is produced by chemical synthesis (folic acid, pteroylglutamic acid) or natural derivation (L-5-methyltetrahydrofolate, 5-MTHF).
It delivers the biologically active form needed for one-carbon metabolism, DNA synthesis, homocysteine regulation, and prevention of neural tube defects in pregnancy. 5-MTHF is preferred for individuals with MTHFR polymorphisms.