D-Mannose is a natural C-2 epimer of glucose produced by enzymatic conversion of fructose or extraction from plant sources (cranberry, birch, corn). It is minimally metabolised and rapidly excreted in urine, where it binds to type-1 fimbriae of E.
Coli and prevents bacterial adhesion to the bladder wall. Widely used in UTI-prevention supplements and women's-health products.