Safety of Long-term Large Doses of Aspartame
Arthur S. Leon, MD; Donald B. Hunninghake, MD; Catherine Bell, MBA; David K. Rassin, PhD; Thomas R. Tephly, MD, PhD
Safety of long-term administration of 75 mg/kg of aspartame per day was evaluated with the use of a randomized, doubleblind, placebo-controlled, parallel-group design in 108 male and female volunteers aged 18