L-Citrulline Malate Side Effects

Citrulline Malate is a supplement can reduce muscle fatigue and detox muscle tissue by removing ammonia. Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is L-Citrulline Malate?

Citrulline is a non-essential amino acid, while malate (or malic acid) is a salt compound primarily found in apples and other fruits. As you might have guessed, citrulline malate is formed when citrulline and malic acid are bonded together. Citrulline malate can be used as a supplement for muscle building and fat loss.

Possible Side Effects of L-Citrulline Malate

Although L-Citrulline Malate generally regarded as a very safe and effective supplement, there can be some minor side effects. The side effects may:

  • stomach discomfort

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. L-Citrulline Malate is considered safe.

Suggested Dosage

  • Start with a once-daily dose of 6-8g (Altius pre-workout contains 8g of citrulline malate per serving)
  • If desired, dose may be increased to 15-20g split into multiple doses throughout the day

Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to L-Cysteine populations. Better consult to your doctor if you would like to intake L-Citrulline Malate.




Related Research

1. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: A clinical trial. [J Cardiol. 2014 Feb 10] Author: Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, Behzadnia N, Sheybani-Afshar F, Fakhri M, Chaibakhsh S, Naghashzadeh F, Aidenlou S.

2. L-citrulline-malate influence over branched chain amino acid utilization during exercise. [Eur J Appl Physiol. 2010 Sep] Author: Sureda A, Córdova A, Ferrer MD, Pérez G, Tur JA, Pons A.

Leave a Comment