Glycerol Side Effects

Glycerol E422 is a simple polyol compound. It is a colorless, odorless, viscous liquid that is sweet-tasting and non-toxic. Though Glycerol E422 is considered safe, some are convinced it has potentially dangerous health effects.

What Is Glycerol E422?

Glycerol E422 is a clear, colorless, syrupy liquid with a greasy texture. This product is used in food as a solvent, sweetener, preservative, filler and thickening agent. Glycerol is found in processed baked goods, liqueurs, beverages and confectionery products.

Possible Side Effects of Glycerol E422

Glycerol E422 is generally considered a safe ingredient. Gastrointestinal side effects associated with rectal administration have included rectal discomfort, irritation, burning or griping, cramping pain, tenesmus, abdominal discomfort, and diarrhea. Hyperemia of the rectal mucosa with minimal amounts of hemorrhage and mucus discharge has been reported.

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Glycerol E422 is considered safe by FDA.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Glycerol populations. Better consult to your doctor if you would like to intake Glycerol.



Related Research

1. Metabolic parameters in rats receiving different levels of oral glycerol supplementation. [J Anim Physiol Anim Nutr (Berl). 2014 Jul 4] Author: Lisenko KG, Andrade EF, Lobato RV, Orlando DR, Damin DH, Costa AC, Lima RR, Alvarenga RR, Zangeronimo MG, Sousa RV, Pereira LJ.

2. Acute oral toxicity evaluation of symmetrically branched glycerol trimer in ddY mice. [J Toxicol Sci. 2012] Author: Miyamoto L, Watanabe M, Tomida Y, Kono M, Fujii S, Matsushita T, Hattori H, Ishizawa K, Nemoto H, Tsuchiya K.

3. A randomized, double-blind comparison shows the addition of oxygenated glycerol triesters to topical mentholated cream for the treatment of acute musculoskeletal pain demonstrates incremental benefit over time. [Pain Pract. 2012 Nov] Author: Taylor R Jr, Gan TJ, Raffa RB, Gharibo C, Pappagallo M, Sinclair NR, Fleischer C, Tabor A.

4. Percutaneous glycerol rhizotomy for trigeminal neuralgia: safety and efficacy of repeat procedures. [Br J Neurosurg. 2011 Apr] Author: Harries AM, Mitchell RD.

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