Ferrous Gluconate Side Effects

Ferrous gluconate E579 or Iron(II) gluconate, is a black compound often used as an iron supplement. It is the iron(II) salt of gluconic acid. Though Ferrous gluconate E579 is considered safe, some are convinced it has potentially dangerous health effects.

What Is Ferrous Gluconate E579?

Ferrous Gluconate E579 is an iron nutrition enhancer that appears as a yellow to gray or light green color, in the form of powder or granules. This product has a slightly caramel-like odor and is soluble in water. Ferrous Gluconate is used in cereal products, dairy products, infant food, beverages, and black olives.

Possible Side Effects of Ferrous Gluconate E579

  • Gastrointestinal

    Frequency not reported: Gastrointestinal discomfort, anorexia, diarrhea, nausea, heartburn, vomiting, constipation, fecal impaction, darkening of stools, gastrointestinal necrosis, gastrointestinal perforation, gastrointestinal stricture, epigastric pain, hematemesis.


    Frequency not reported: Allergic reactions


    Frequency not reported: Circulatory collapse

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Ferrous Gluconate E579 is considered safe by FDA.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Ferrous Gluconate populations. Better consult to your doctor if you would like to intake Ferrous Gluconate.


Related Research

1. Bioavailability of stabilised ferrous gluconate with glycine in fresh cheese matrix: a novel iron compound for food fortification. [Biol Trace Elem Res. 2013 Mar] Author: Pizarro F, Boccio J, Salgueiro M, Olivares M, Carmuega E, Weill R, Marque S, Frereux M, Noirt F.

2. Iron polymaltose versus ferrous gluconate in the prevention of iron deficiency anemia of infancy. [J Pediatr Hematol Oncol. 2010 Nov] Author: Jaber L, Rigler S, Taya A, Tebi F, Baloum M, Yaniv I, Haj Yehia M, Tamary H.

3. Ferrous gluconate and ferrous sulfate added to a complementary food distributed by the Mexican nutrition program Oportunidades have a comparable efficacy to reduce iron deficiency in toddlers. [J Pediatr Gastroenterol Nutr. 2008 Nov] Author: Shamah-Levy T, Villalpando S, Rivera-Dommarco JA, Mundo-Rosas V, Cuevas-Nasu L, Jiménez-Aguilar A.

4. Fortifying milk with ferrous gluconate and zinc oxide in a public nutrition program reduced the prevalence of anemia in toddlers. [J Nutr. 2006 Oct] Author: Villalpando S, Shamah T, Rivera JA, Lara Y, Monterrubio E.

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