L-Proline Side Effects

L-Proline is used in the food and beverage industry as a nutritional supplement and as a flavoring agent. It can be used as a spice, cheeses, meat products, and yogurts, etc. Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is L-Proline?

L-Proline is a non-essential amino acid synthesized in the body via breakdown of L-glutamate. It is found naturally in protein-rich foods such as meat, eggs, and dairy. L-Proline is important for collagen production, joint health, proper immune function, and cellular health. It is used as a component of dietary supplements such as protein powders

Possible Side Effects of L-Proline

Though L-Proline is regarded as safe supplement, there maybe some side effects:

  • Flushing
  • Bloating
  • Blurred vision
  • Abnormal heart rhythm
  • Toxic impaired or dim vision
  • Inflammation of the liver

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. L-Proline is considered safe.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to L-Proline populations. Better consult to your doctor if you would like to intake L-Proline.



Related Research

1. Effects of L-proline on the Growth Performance, and Blood Parameters in Weaned Lipopolysaccharide (LPS)-challenged Pigs. [Asian-Australas J Anim Sci. 2014 Aug] Author: Kang P, Zhang L, Hou Y, Ding B, Yi D, Wang L, Zhu H, Liu Y, Yin Y, Wu G.

2. Chiral separation and determination of amino acids in real samples by LE-MEKC using Cu(II)-l-proline as chiral selector. [J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 15] Author: Wu Y, Zhai Y, Zhang Y, Zhang H, Jing H, Chen A.

3. Synthesis of Oligomers of β-l-Arabinofuranosides of (4R)-4-Hydroxy-l-proline Relevant to the Mugwort Pollen Allergen, Art v 1. [J Org Chem. 2014 Aug 1. ] Author: Xie N, Taylor CM.

4. Novel inhibitors of the high-affinity l-proline transporter as potential therapeutic agents for the treatment of cognitive disorders. [Bioorg Med Chem Lett. 2014 Jul 1.] Author: Zipp GG, Barbosa J, Green MA, Terranova KM, Fink C, Yu XC, Nouraldeen A, Wilson A, Savelieva K, Lanthorn TH, David Kimball S.

5. Clinical Experience With an L-Proline-Stabilized 10 % Intravenous Immunoglobulin (Privigen®): Real-Life Effectiveness and Tolerability. [J Clin Immunol. 2014 Jul 1. ] Author: Dorsey MJ, Ho V, Mabudian M, Soler-Palacín P, Domínguez-Pinilla N, Rishi R, Rishi R, Wong D, Rojavin M, Hubsch A, Berger M.

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