Microcrystalline Cellulose Side Effects

Microcrystalline cellulose E460 is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. The most common form is used in vitamin supplements or tablets.  Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is Microcrystalline Cellulose E460?

Microcrystalline Cellulose (MCC) E460 is a term for refined wood pulp, and it appears as a fine white to off-white powder. This product is mainly used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in pasteurized cream, fermented milk, cheese, processed fruit, dried vegetables, etc. It is also used in vitamin supplements or tablets

Possible Side Effects of Microcrystalline Cellulose E460

Although Microcrystalline Cellulose E460 generally regarded as a very safe and effective supplement, there can be some minor side effects. The side effects may:

  • Microcrystalline Cellulose may cause mild side effects in certain individuals. You may find that you have to frequent the bathroom more often due to an increase in stool production. You may also experience gas and bloating.Other reported side effects include depression, forgetfulness, lack of energy, and headaches. One woman determined her rash, irregular heartbeat, and loss of hair was due to an allergic reaction to Microcrystalline Cellulose.

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Microcrystalline Cellulose E460 is considered safe by FDA.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to L-Malic Acid populations. Better consult to your doctor if you would like to intake Microcrystalline Cellulose.




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