Nisin Side Effects

Nisin E234 is a polycyclic antibacterial peptide produced by the bacterium Lactococcus lactis that is used as a food preservative. Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is Nisin E234?

Nisin E234 is used as a preservative in the form of off-white or yellowish powder. It is used during production to prolong the shelf life by minimizing gram-positive spoilage and pathogenic bacteria. Applications include processed beverages, cheese and meats.

Possible Side Effects of Nisin E234

Although Nisin E234 generally regarded as a very safe and effective supplement, there can be some minor side effects. Possible side effects: pruritus, nausea, and flushing. Other side effects include: pruritus, skin rash, and vomiting.

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Nisin E234 is considered safe by FDA.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Nisin populations. Better consult to your doctor if you would like to intake Nisin E234.



Related Research

1. Genome shuffling of Lactococcus lactis subspecies lactis YF11 for improving nisin Z production and comparative analysis. [J Dairy Sci. 2014 May] Author: Zhang YF, Liu SY, Du YH, Feng WJ, Liu JH, Qiao JJ.

2. Activate to eradicate: inhibition of Clostridium difficile spore outgrowth by the synergistic effects of osmotic activation and nisin. [PLoS One. 2013] Author: Nerandzic MM, Donskey CJ.

3. Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1. [Cancer Med. 2012 Dec] Author: Joo NE, Ritchie K, Kamarajan P, Miao D, Kapila YL.

4. Evaluation of antimicrobial peptide nisin as a safe vaginal contraceptive agent in rabbits: in vitro and in vivo studies.[Reproduction. 2004 Jul] Author: Reddy KV, Aranha C, Gupta SM, Yedery RD.

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