Natamycin Side Effects

Natamycin E235, also known as pimaricin and sometimes sold as Natacyn, is a naturally occurring antifungal agent produced during fermentation by the bacterium Streptomyces natalensis, commonly found in soil. Natamycin has been used for decades in the food industry as a hurdle to fungal outgrowth in dairy products and other foods. Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is Natamycin E235?

Natamycin E235 is used to inhibit fungal outgrowth in dairy products, meats, and other foods. It is also used in cottage cheese, sour cream, yogurt, and packaged salad mixes. Natamycin E235 is a cream white crystalline powder. It has been globally used in cheese, juice, fresh ham, wine and in the meat industry. This product has no effect on bacteria, so it does not prevent in the natural maturing process of food.

Possible Side Effects of Natamycin E235

Although Natamycin E235 generally regarded as a very safe and effective supplement, there can be some minor side effects. Possible side effects: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Natamycin E235 is considered safe by FDA.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Natamycin populations. Better consult to your doctor if you would like to intake Natamycin E235.




Related Research

1. Voriconazole versus natamycin as primary treatment in fungal corneal ulcers. [Clin Experiment Ophthalmol. 2011 Jul] Author: Arora R, Gupta D, Goyal J, Kaur R.

2. Successful salvage treatment of Scedosporium apiospermum keratitis with topical voriconazole after failure of natamycin. [Ann Pharmacother. 2009 Jun] Author: Al-Badriyeh D, Leung L, Davies GE, Stewart K, Kong D.

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