Sodium Cyclamate Side Effects

Sodium Cyclamate E952 Side Effects

Sodium Cyclamate E952 is a artificial sweetener with zero calorie used in sugar-free products. It’s not considered safe by the Food and Drug Administration (FDA), and some are convinced it has potentially dangerous health effects.

What Is It?

Sodium Cyclamate, CAS number 139-05-9, E number E952, used as sweetener as it is 30–50 times sweeter than sugar. Sodium Cyclamate is a sodium salt of cyclamic acid manufactured through chemical synthesis, CP95 (flaky crystalline powder) and NF13 (needle-shaped). It is used a sugar substitute in soft drinks, liquors, seasonings, cakes, biscuits, bread, and ice cream.

Possible Side Effects of Sodium Cyclamate E952

Cancer Risk: Rats given cyclamate may develop bladder cancer.

Male Fertility effects: Rats had negative side effects like testicular atrophy but mice did not.  Cyclamate is composed to Cyclohexylamine, which could cause testicular atrophy in rats.

GRAS Affirmation: NOT

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements.

The U.S. Food and Drug Administration banned the use of cyclamate in 1969 due to concerns about its cancer risk in animals. The FDA has not yet to agree to use cyclamate through some research show it was safe.

Suggested Dosage

Dosage of Sodium Cyclamate E952 in large quantity may hurt our health, please follow the guideline of using Sodium Cyclamate: ADI 0-7 mg/per kilogram of body weight
* ADI: Acceptable Daily Intake
* MTDI: maximum tolerable daily intake
* Data source: JECFA Database of WHO

Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Sucralose populations. As with most things for Newborns, children, pregnant, it is always best to consult with your health care provider about what artificial ingredients are safe for you to use.
Sodium Cyclamate is safe and suitable for all segments of the population. There is no evidence that Sodium Cyclamate E952 could have any side effects on these vulnerable populations.

Yet, some people still believe that the use of Sodium Cyclamate E952 should be limited in infants, children, and pregnant women.

How to avoid Sodium Cyclamate E952

By reading the labels of the foods and drinks you purchase, you should be able to identify the sweetener. It will be listed as Sodium Cyclamate, according to the FDA. It could also be labeled under the brand names.

As it’s a sugar replacement sweetener, you will largely find it in sugar-free or low-sugar products. Diet sodas may be sweetened with a combination of Sodium Cyclamate and other artificial sweeteners.

Related Research

1. Rapid analysis of cyclamate in foods and beverages by gas chromatography-electron capture detector (GC-ECD). [Food Chem. 2012 Oct] Author: Yu S, Zhu B, Lv F, Li S, Huang W.

2. The safety of cyclamate–an artificial sweetener. [Med Lett Drugs Ther. 1969 Oct] Author: [No authors listed]

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