Calcium Acetate Side Effects

Calcium acetate E263 is a calcium salt of acetic acid. It is used n food as used as a chelating agent, suppressing mold agent, stabilizer, buffer, flavoring agent, preservative, curing agent, and nutrition fortifie. Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is Calcium Acetate E263?

Calcium Acetate E263 comes as a hemihydrate in the form of a fine white bulky powder or granular grade that is used as a sequestrant, thickener, or for pH control. Calcium Acetate is mainly used in the production of candy products, desserts, and baked good (bread, cakes, pastries).

Possible Side Effects of Calcium Acetate E263

Though Calcium Acetate E263 is regarded as safe supplement, there maybe some side effects (from

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking calcium acetate:

More common:

  • Abdominal or stomach pain
  • confusion
  • constipation
  • depression
  • dry mouth
  • full or partial loss of consciousness
  • headache
  • incoherent speech
  • increased urination
  • loss of appetite
  • metallic taste
  • muscle weakness
  • nausea or vomiting
  • thirst
  • unusual tiredness
  • weight loss

Incidence not known:

  • Swelling

Minor Side Effects

Some of the side effects that can occur with calcium acetate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

  • Diarrhea

Less common:

  • Itching

Incidence not known:

  • Dizziness
  • weakness

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Calcium Acetate is considered safe.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Calcium Acetate populations. Better consult to your doctor if you would like to intake Calcium Acetate E263.



Related Research

1. Efficacy and safety of sevelamer hydrochloride and calcium acetate in patients on peritoneal dialysis [Nephrol Dial Transplant. 2009 Jan] Author: Evenepoel P, Selgas R, Caputo F, Foggensteiner L, Heaf JG, Ortiz A, Kelly A, Chasan-Taber S, Duggal A, Fan S.

2. Comparative effectiveness of calcium acetate and sevelamer on clinical outcomes in elderly hemodialysis patients enrolled in medicare part d. [Am J Kidney Dis. 2014 Jul] Author: Yusuf AA, Weinhandl ED, St Peter WL.

3. A comparison of calcium acetate/magnesium carbonate and sevelamer-hydrochloride effects on fibroblast growth factor-23 and bone markers: post hoc evaluation from a controlled, randomized study. [Nephrol Dial Transplant. 2013 Sep] Author: Covic A, Passlick-Deetjen J, Kroczak M, Büschges-Seraphin B, Ghenu A, Ponce P, Marzell B, de Francisco AL.

4. Comparison of calcium acetate and sevelamer on vascular function and fibroblast growth factor 23 in CKD patients: a randomized clinical trial. [Am J Kidney Dis. 2012 Feb] Author: Yilmaz MI, Sonmez A, Saglam M, Yaman H, Kilic S, Eyileten T, Caglar K, Oguz Y, Vural A, Yenicesu M, Mallamaci F, Zoccali C.

5. Effect of lanthanum carbonate and calcium acetate in the treatment of hyperphosphatemia in patients of chronic kidney disease. [Indian J Pharmacol. 2009 Aug] Author: Scaria PT, Gangadhar R, Pisharody R.

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