Propylene Glycol Alginate Side Effects

Propylene glycol alginate (PGA) E405 is an additive used mainly as a thickening agent in certain types of food. Though Propylene Glycol Alginate E405 is considered safe, some are convinced it has potentially dangerous health effects.

What Is Propylene Glycol Alginate E405?

Propylene Glycol Alginate E405 is an ester of alginic acid originally derived from brown algae. This product appears as a white or slightly yellowish color and in powder form. It is used as a thickening and emulsifying agent, is acid resistant, and is soluble in water and acid. Propylene Glycol Alginate E405 is used in dairy products, salad dressing, fruit, lactic acid beverages, beer, and instant food.

Possible Side Effects of Propylene Glycol Alginate E405

Though Propylene Glycol Alginate E405 is regarded as safe supplement, there maybe some side effects: It can cause stomach upset and nausea, whether it’s ingested or used on the skin as a cosmetic. When it is only used in cosmetic, it can cause allergic reactions that include hair loss, rashes, and eye irritations. Cosmetic use is the most common cause of side effects. Other skin-related allergies can occur when household cleaners that contains this ingredient are used.

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Propylene Glycol Alginate E405 is considered safe.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Propylene Glycol Alginate E405 populations. Better consult to your doctor if you would like to intake Propylene Glycol Alginate E405.

Related Research

1. Effects of propylene glycol alginate and sucrose esters on the physicochemical properties of modified starch-stabilized beverage emulsions. [Molecules. 2014 Jun 24] Author: Cheong KW, Mirhosseini H, Hamid NS, Osman A, Basri M, Tan CP.

2. Determination of M/G ratio of propylene glycol alginate sodium sulfate by HPLC with pre-column derivatization. [Carbohydr Polym. 2014 Apr 15] Author: Wu J, Zhao X, Ren L, Xue Y, Li C, Yu G, Guan H.

3. Enamel matrix derivative in propylene glycol alginate for treatment of infrabony defects with or without systemic doxycycline: 12- and 24-month results. [J Periodontol. 2014 May] Author: Eickholz P, Röllke L, Schacher B, Wohlfeil M, Dannewitz B, Kaltschmitt J, Krieger JK, Krigar DM, Reitmeir P, Kim TS.

4. Interfacial and foaming interactions between casein glycomacropeptide (CMP) and propylene glycol alginate. [Colloids Surf B Biointerfaces. 2012 Jun 15] Author: Martinez MJ, Pizones Ruiz-Henestrosa VM, Carrera Sánchez C, Rodríguez Patino JM, Pilosof AM.

5. Integrative design of a poly(ethylene glycol)-poly(propylene glycol)-alginate hydrogel to control three dimensional biomineralization. [Biomaterials. 2011 Apr] Author: Cha C, Kim ES, Kim IW, Kong H.

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