L-Citrulline DL-Malate Side Effects

L-Citrulline Malate is a blend of L-Citrulline and Malate; a salt of Malic Acid. Citrulline Malate is an amino acid derived from watermelon that appears as a white to off-white crystalline powder. Citrulline Malate can reduce muscle fatigue and detox muscle tissue by removing ammonia. Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is L-Glutamine?

L-Citrulline DL-Malate is used as either a 2:1 or 1:1 ratio. 2:1 provides a higher ratio of L-Citrulline to Malate than 1:1 and generally costs more. The malic acid component of L-Citrulline Malate has been proven to combat fatigue and promote ATP production (ATP provides energy needed by your body for muscle contractions) while L-Citrulline alone, has not.

Possible Side Effects of Citrulline Malate

L-Citrulline DL-Malate is generally considered a safe ingredient. Research and anecdotal reports show citrulline malate isn’t strongly associated with any side effects.  This is because citrulline malate is a combination of the amino acid citrulline and the natural chemical malic acid, both of which are safe to use regularly. A few participants in one study reported slight stomach discomfort after taking citrulline malate. Even so, less than 15% of the participants reported this side effect. And, in other citrulline malate studies, no side effects were reported. At least for now, it seems citrulline malate is one ingredient you can take without expecting major negative side effects. That quality certainly sets citrulline malate apart from many other ingredients, so it’s no wonder citrulline malate is the go-to supplement for athletes and bodybuilders.

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. L-Citrulline DL-Malate is considered safe by FDA.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to L-Citrulline DL-Malate populations. Better consult to your doctor if you would like to intake L-Citrulline DL-Malate.


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