Retinyl acetate (retinol acetate, vitamin A acetate) is a natural form of vitamin A which is the acetateester of retinol. It has potential antineoplastic and chemopreventive activities. Though it’s considered safe, some are convinced it has potentially dangerous health effects.
What Is Retinyl acetate?
Vitamin A Acetate is a microencapsulated light yellow powder used in solid, liquid drinks, water-based food and ordinary food fortification, but also can be used as tablet and hard capsules. This product is Vitamin A palmitate oil emulsion that after certain vectors is spray-dried to form powder particles.
Possible Side Effects of Retinyl acetate
Although Retinyl acetate generally regarded as a very safe and effective supplement, there can be some minor side effects. The side effects may:
- Difficulty breathing
- Swelling of face
- Discoloration of urine
- Swelling of lips & tongue
- Skin irritation
GRAS Affirmation: Yes
Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Retinyl acetate is considered safe.
Special Populations Precaution
There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Retinyl acetate populations. Better consult to your doctor if you would like to intake Retinyl acetate.
1. Simultaneous determination of 13-cis and all-trans vitamin A palmitate (retinyl palmitate), vitamin A acetate (retinyl acetate), and total vitamin E (alpha-tocopherol and DL-alpha-tocopherol acetate) in infant formula and adult nutritionals by normal phase HPLC: first action 2012.10. [J AOAC Int. 2013 Sep-Oct] Author: McMahon A, Christiansen S, Shine L, Loi C, Dowell D.
2. Nanoscale domains with nematic order in supercooled vitamin-A acetate: molecular dynamics studies. [Phys Rev E Stat Nonlin Soft Matter Phys. 2011 May] Author: Wojnarowska Z, Paluch M, Wlodarczyk P, Hawelek L, Wrzalik R, Zioło J, Wygledowska-Kania M, Bergler-Czop B, Brzezinska-Wcislo L, Bujak P.
3. Preparation, in vitro and in vivo evaluation of solid-state self-nanoemulsifying drug delivery system (SNEDDS) of vitamin A acetate. [J Drug Target. 2009 Jul;] Author: Taha EI, Al-Suwayeh SA, Anwer MK.
4. Effectiveness of vitamin A acetate for enhancing the production of lung cancer specific monoclonal antibodies. [Cytotechnology. 1999 Sep] Author: Inoue Y, Fujisawa M, Kawamoto S, Shoji M, Hashizume S, Fujii M, Katakura Y, Shirahata S.
5. Alterations in gene expression in rat skin exposed to 56Fe ions and dietary vitamin A acetate. [Radiat Res. 2006 May] Author: Zhang R, Burns FJ, Chen H, Chen S, Wu F.