Side Effect of Trisodium Phosphate

Trisodium Phosphate E339(iii) is a food preservative used in red meats, poultry, and seafood, helping them to retain their tenderness and moisture during storage and transport. Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is Trisodium Phosphate E339(iii)?

Trisodium Phosphate E339(iii) (TSP), Na3PO4.12H2O, is a white or colorless crystal that is efflorescent in air. It is easily soluble in water but is insoluble in organic solutions. Food grade Trisodium Phosphate (TSP) is used as an acidity regulator, an emulsifier, a humectant, a raising agent, a sequestrant, a stabilizer, and a thickening agent.

Possible Side Effects of Trisodium Phosphate E339(iii)

Though Trisodium Phosphate E339(iii) is regarded as safe supplement, there maybe some side effects: irritate your stomach lining, causing stomach pain and gastrointestinal upset.

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Trisodium Phosphate E339(iii) is considered safe.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Trisodium Phosphate populations. Better consult to your doctor if you would like to intake Trisodium Phosphate E339(iii).



Related Research

1. Safety first: the case against oral sodium phosphate. [Endoscopy. 2014 Jun] Author: Rao S, Calderwood AH.

2. The efficacy and safety of colonoscopy preparation with oral sodium phosphate in elderly patients [Turk J Gastroenterol. 2010 Jun] Author: Yakut M, Cinar K, Seven G, Cetınkaya H, Bahar K.

3. Efficacy and safety of sodium phosphate for colon cleansing in type 2 diabetes mellitus. [South Med J. 2010 Nov] Author: Ozturk NA, Gokturk HS, Demir M, Unler GK, Gur G, Yilmaz U.

4. Colon cleansing with oral sodium phosphate in adolescents: dose, efficacy, acceptability, and safety. [Am J Gastroenterol. 2008 Jun] Author: Sabri M, Di Lorenzo C, Henderson W, Thompson W, Barksdale E Jr, Khan S.

5. The renal safety of bowel preparations for colonoscopy: a comparative study of oral sodium phosphate solution and polyethylene glycol. [Aliment Pharmacol Ther. 2008 Jan 1] Author: Singal AK, Rosman AS, Post JB, Bauman WA, Spungen AM, Korsten MA

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