Tertiary Butylhydroquinone Side Effects

Tert-Butylhydroquinone (TBHQ, tertiary butylhydroquinone) E319 is used as a preservative for unsaturated vegetable oils and many edible animal fats. Though Tert-Butylhydroquinone E319 is considered safe, some are convinced it has potentially dangerous health effects.

What Is Tertiary Butylhydroquinone E319?

Tertiary butylhydroquinone (TBHQ) E319 is a white or light mahogany crystalline powder that is soluble in ethanol, acetic acid, ethyl ester, aether and vegetable oil, and lard. It plays a role in antisepsis for most of the oils, especially vegetable oil. This product is often used in margarine, nuts, potato chips, instant noodles, and oils.

Possible Side Effects of Tertiary butylhydroquinone (TBHQ) E319

Although Tertiary Butylhydroquinone E319 generally regarded as a very safe and effective supplement, there can be some minor side effects. The side effects may:

  • nausea, vomiting, ringing in the ears, delirium and collapse.

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Tertiary Butylhydroquinone is considered safe.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Tertiary Butylhydroquinone populations. Better consult to your doctor if you would like to intake Tertiary Butylhydroquinone.




Related Research

1. Tertiary-butylhydroquinone upregulates expression of ATP-binding cassette transporter A1 via nuclear factor E2-related factor 2/heme oxygenase-1 signaling in THP-1 macrophage-derived foam cells. [Circ J. 2013] Author: Lu Q, Tang SL, Liu XY, Zhao GJ, Ouyang XP, Lv YC, He PP, Yao F, Chen WJ, Tang YY, Zhang M, Zhang DW, Yin K, Tang CK.

2. Oxidative stability of virgin olive oil as affected by the bene unsaponifiable matters and tertiary-butylhydroquinone. [J Food Sci. 2012 Jun] Author: Farhoosh R, Haddad Khodaparast MH, Sharif A, Zamani-Ghalehshahi A, Hoseini-Yazdi SZ.

3. Determination of tertiary-butylhydroquinone and its metabolites in rat serum by liquid chromatography-ion trap mass spectrometry. [Lipids. 2008 Mar] Author: Huang W, Gu Y, Niu H.

4. Allergic contact dermatitis from tertiary-butylhydroquinone and Laureth 12 in a hair dye. [Contact Dermatitis. 2007 Feb] Author: Field S, Hazelwood E, Bourke B, Bourke JF.

5. Allergic contact dermatitis from tertiary-butylhydroquinone (TBHQ) in a vegetable hydraulic oil. [Contact Dermatitis. 2000 Nov] Author: Aalto-Korte K.

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