D-Glucuronolactone Side Effects

Glucuronolactone is a natural, white solid compound. It is odorless and soluble in hot and cold water. Glucuronolactone is commonly used as a detoxifier in energy drinks. Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is D-Glucuronolactone?

D-Glucuronolactone is used as a supplement in certain sports energy drinks; most notably Red Bull. Glucuronolactone is implicated as an agent which may be helpful for enhancing cardiovascular functioning, improving athletic performance and promoting alertness.

Possible Side Effects of D-Glucuronolactone

Glucuronolactone is widely consumed in energy drinks and is generally well tolerated. There are no safety warnings issued by the FDA for this supplement. Also, the EFSA (European Food Safety Association) has stated that there is no risk of glucuronolactone toxicity due to exposure from routine consumption of certain energy drinks.

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. D-Glucuronolactone is considered safe.

Suggested Dosage

Doses of 350mg glucuronolactone have been found to be effective for use as a pre workout supplement (Hoffman et al, 2008). The effects of glucuronolactone set in fairly rapidly. It has been reported that consuming a supplement containing glucuronolactone 10 minutes before exercise resulted in improved exercise performance (Hoffman et al, 2008). However, given that glucuronolactone typically occurs with other ingredients, it is recommended for such supplements to be consumed 30 to 45 minutes before a workout, or as indicated by the manufacturer.

Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to D-Glucuronolactone populations. Better consult to your doctor if you would like to intake D-Glucuronolactone.