L-Malic Acid Side Effects

L-Malic acid E296 is often used in the food processing and concoction of beverage, liqueur, fruit juice, candy, jams, etc. It can inhibit bacteria growth and remove tartrate during wine brewing. Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is L-Malic Acid E296?

L-Malic Acid E296 is a white crystalline powder that is fairly hygroscopic and dissolves easily in water and alcohol. As an acidulant, L-Malicacid is especially suitable for jelly and foodstuff containing fruit ingredients. It can keep the natural color of juice. Used in healthy drinks, it can help to resist fatigue and protect the liver, kidney and heart. L-Malic acid E296 can enhance pharmaceutical stability and improve pharmaceutical absorption. It can be added into composite amino acid injection, directly participating the metabolic cycle of organism-Krebs cycle. It can reduce the metabolic loss of amino acid and can compensate hypohepatia, cure uremia and hypertension, and weaken the damage of anticancer drug to normoblasts. It is also used as a skin disinfector, air depurative and deodorizer.

Possible Side Effects of L-Malic Acid E296

Although L-Malic acid E296 generally regarded as a very safe and effective supplement, there can be some minor side effects. The side effects may:

  • irritation of the mouth, throat or stomach
  • gas
  • diarrhea
  • upset stomach
  • acid reflux

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. L-Malic Acid E296 is considered safe by FDA.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to L-Malic Acid E296 populations. Better consult to your doctor if you would like to intake L-Malic Acid E296.




Related Research

1. Microbial biosynthesis and secretion of l-malic acid and its applications. [Crit Rev Biotechnol. 2014 Jul 15] Author: Chi Z, Wang ZP, Wang GY, Khan I, Chi ZM.

2. Preparation and pH controlled release of polyelectrolyte complex of poly(L-malic acid-co-D,L-lactic acid) and chitosan. [Colloids Surf B Biointerfaces. 2014 Mar 1] Author: Wang J, Ni C, Zhang Y, Zhang M, Li W, Yao B, Zhang L.

3. Metabolic engineering of Aspergillus oryzae NRRL 3488 for increased production of L-malic acid. [Appl Microbiol Biotechnol. 2013 Oct] Author: Brown SH, Bashkirova L, Berka R, Chandler T, Doty T, McCall K, McCulloch M, McFarland S, Thompson S, Yaver D, Berry A.

4. The cardioprotective effects of citric Acid and L-malic Acid on myocardial ischemia/reperfusion injury. [Evid Based Complement Alternat Med. 2013] Author: Tang X, Liu J, Dong W, Li P, Li L, Lin C, Zheng Y, Hou J, Li D.

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