Bonito Elastin Peptide provides a rare source of bioavailable elastin-derived peptides containing the unique pyridinium crosslinks desmosine and isodesmosine, which are characteristic only of elastin protein. These peptides are absorbed intact through the intestinal peptide transporter and exert systemic effects: promoting elastin synthesis in skin fibroblasts. It supports vascular wall elasticity, and contributing to joint cartilage maintenance.
Production involves extraction from bonito arteries/bulbus arteriosus and ligaments followed by controlled enzymatic hydrolysis with food-grade proteases (papain, bromelain, or microbial proteases). Standardized to ≥ 5 μg/g desmosine content. Clinical research from Japanese universities demonstrates skin elasticity improvements, reduced wrinkle depth, and improved blood vessel flexibility with daily oral doses of 75–200 mg. Meets FDA GRAS, Japan FOSHU, and EU Novel Food regulatory standards.