Vitamin D3 Side Effects

Vitamin D3 is also known as Cholecalciferol. It is a dry derivative of Vitamin D3 and is supplied at 40,000,000 IU Vitamin D3/gram. Vitamin D3 can be taken as a supplement to improve overall health or used to treat osteoporosis. It is suitable for dietary supplements, food preparations and pharmaceutical applications. Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is Vitamin D3?

Vitamin D3 is a white or yellowish-white powder used in the food industry used as a nutrition intensifying agent. Applications for Vitamin D3 include milk powder, lacovo, nutrient supplement in meal replacement beverages and bars.

Possible Side Effects of Vitamin D3

Although Vitamin D3 generally regarded as a very safe and effective supplement, there can be some minor side effects. The side effects may:

  • Cough
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • hives or itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Vitamin D3 is considered safe.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Vitamin D3 populations. Better consult to your doctor if you would like to intake Vitamin D3.



Related Research

1. High-Dose Vitamin D3 Supplementation in Children and Young Adults with HIV: A Randomized, Placebo-Controlled Trial. [Pediatr Infect Dis J. 2014 Jul 1] Author: Stallings VA, Schall JI, Hediger ML, Zemel BS, Tuluc F, Dougherty KA, Samuel JL, Rutstein RM.

2. Beneficial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study. [Ann Allergy Asthma Immunol. 2014 Apr] Author: Rorie A, Goldner WS, Lyden E, Poole JA.

3. A Double-Blind, Placebo Controlled, Randomized Trial to Assess the Impact of a Monthly Administration of 50,000 IU of Vitamin D3 for 6 Months on Serum Levels of 25-Hydroxyvitamin D in Healthy Young Adults. [Int J Endocrinol. 2013] Author: Brunel E, Schnitzler M, Foidart-Dessalle M, Souberbielle JC, Cavalier E.

4. Vitamin D3 inhibits expression and activities of matrix metalloproteinase-2 and -9 in human uterine fibroid cells. [Hum Reprod. 2013 Sep] Author: Halder SK, Osteen KG, Al-Hendy A.

5. A Randomised, Double-Blinded, Placebo-Controlled, Parallel Study of Vitamin D3 Supplementation with Different Schemes Based on Multiples of 25,000 IU Doses. [Int J Endocrinol. 2013] Author: Cavalier E, Faché W, Souberbielle JC.

One Response to “Vitamin D3 Side Effects”

By Valerie Young - 30 December 2019

I read that too much Vitamin D3 can cause frequent urination is this true?

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