Calcium Gluconate Side Effects

Calcium Gluconate E578 is a mineral supplement that is manufactured by the neutralization of gluconic acid with lime or calcium carbonate. It is in the form of a white crystal powder and has the chemical formula of C12H22CaO14H2O. Calcium Gluconate can be used in nutritional supplements and nutrition bars.  Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is Calcium Gluconate E578?

Calcium Gluconate E578 is a white crystalline granule or powder that functions as a firming agent, formulation aid, sequestrant, and stabilizer. It is used as a source of calcium ions for sodium alginate gels, and as a calcium fortifier in baked goods, puddings, and dairy product analogs. It can also mask the bitter aftertaste of some artificial sweeteners.

Possible Side Effects of Calcium Gluconate E578

Although Calcium Gluconate E578 generally regarded as a very safe and effective supplement, there can be some minor side effects. The side effects may:

  • nausea
  • vomiting
  • decreased appetite
  • constipation
  • dry mouth
  • increased thirst
  • increased urination
  • tingling sensations

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Calcium Gluconate E578 is considered safe.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Calcium Gluconate populations. Better consult to your doctor if you would like to intake Calcium Gluconate.




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