Chondroitin Sulfate Side Effects

Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid). Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is Chondroitin sulfate?

Chondroitin Sulfate is a food additive or dietary supplement normally found in cartilage around joints in the body. Chondroitinsulfate is derived and manufactured from animal sources, such as bovine, porcine, poultry or shark cartilage. It is traditionally used in the treatment of osteoarthritis, high blood pressure, anemia, and heart disease. It can also be used as a remedy for dry eyes in the form of manufactured eye drops.

Possible Side Effects of Chondroitin sulfate

Although Chondroitin sulfate generally regarded as a very safe and effective supplement, there can be some minor side effects. The side effects may:

    • Nausea
    • Diarrhea
    • Gastrointestinal upset

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Chondroitin sulfate is considered safe.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Chondroitin sulfate populations. Better consult to your doctor if you would like to intake Chondroitin sulfate.




Related Research

1. Ternary complex of plasmid DNA electrostatically assembled with polyamidoamine dendrimer and chondroitin sulfate for effective and secure gene delivery. [Biol Pharm Bull. 2014] Author: Imamura M, Kodama Y, Higuchi N, Kanda K, Nakagawa H, Muro T, Nakamura T, Kitahara T, Sasaki H.

2. Combined intravesical sodium hyaluronate/chondroitin sulfate therapy for interstitial cystitis/bladder pain syndrome: a prospective study. [Ther Adv Urol. 2013 Aug] Author: Giberti C, Gallo F, Cortese P, Schenone M.

3. Symptom and structure modification in osteoarthritis with pharmaceutical-grade chondroitin sulfate: what’s the evidence? [Curr Med Res Opin. 2013 Mar] Author: Hochberg M, Chevalier X, Henrotin Y, Hunter DJ, Uebelhart D.

4. Combination of chondroitin sulfate and polyplex micelles from Poly(ethylene glycol)-poly{N’-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity. [J Control Release. 2011 Oct 30] Author: Uchida S, Itaka K, Chen Q, Osada K, Miyata K, Ishii T, Harada-Shiba M, Kataoka K.

5. Chondroitin sulfate capsule system for efficient and secure gene delivery. [J Pharm Pharm Sci. 2010] Author: Kurosaki T, Kitahara T, Fumoto S, Nishida K, Yamamoto K, Nakagawa H, Kodama Y, Higuchi N, Nakamura T, Sasaki H.

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