D-Aspartic Acid Side Effects

Aspartic acid, also known as aspartate, is an α-amino acid that is used in the biosynthesis of proteins. Similar to all other amino acids it contains an amino group and a carboxylic acid. Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is D-Aspartic Acid?

D-Aspartic Acid is a White or white crystalline powder with the molecular formula (C4H7NO2). Primarily used as a nutraceutical, it is considered to be a nutrition enhancer and can be found in many nutritional supplements or as an additive in many foods.

Possible Side Effects of D-Aspartic Acid

D-Aspartic Acid is generally considered a safe ingredient. The side effects may:

  • Acne
  • Headache
  • Diarrhea
  • Mood Swings
  • Depression

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. D-Aspartic Acid is considered safe by FDA.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to D-Aspartic Acid populations. Better consult to your doctor if you would like to intake D-Aspartic Acid.



Related Research

1. D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men. [Nutr Res. 2013 Oct] Author: Willoughby DS, Leutholtz B.

2. Decreased levels of free D-aspartic acid in the forebrain of serine racemase (Srr) knock-out mice. [Neurochem Int. 2013 May] Author: Horio M, Ishima T, Fujita Y, Inoue R, Mori H, Hashimoto K.

3. Gender differences in D-aspartic acid content in skull bone. [Hiroshima J Med Sci. 2012 Dec] Author: Torikoshi-Hatano A, Namera A, Shiraishi H, Arima Y, Toubou H, Ezaki J, Morikawa M, Nagao M.

4. D-Aspartic acid implication in the modulation of frog brain sex steroid levels. [Gen Comp Endocrinol. 2013 Jan 15] Author: Santillo A, Pinelli C, Burrone L, Chieffi Baccari G, Di Fiore MM.

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