L-Valine Side Effects

L-Valine is an amino acid used as food or dietary supplements. It is a branched chain amino acid, widely used in the production of pharmaceutical, food and condiment, cosmetic and medical applications. Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is L-Valine?

L-Valine  known an amino acid & a branched-chain amino acid member found in high concentration in the muscles. It has a stimulating effect and is needed for muscle metabolism, repair and growth of tissue and maintaining the nitrogen balance in the body. Since it is a branched-chain amino acid, it can be used as an energy source in the muscles, and in doing so preserves the use of glucose.

Possible Side Effects of L-Valine

L-Valine is generally considered a safe ingredient. The side effects may: with liver and/or kidney disease should not take this supplement. It should not be consumed in excess, as it can cause even hallucinations in severe cases.

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. L-Valine is considered safe by FDA.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to L-Valine populations. Better consult to your doctor if you would like to intake L-Valine.

Related Research

1. Application of metabolic engineering for the biotechnological production of L-valine. [Appl Microbiol Biotechnol. 2014 Jul] Author: Oldiges M, Eikmanns BJ, Blombach B.

2. Conformation of dehydropentapeptides containing four achiral amino acid residues – controlling the role of L-valine. [Beilstein J Org Chem. 2014 Mar 14] Author: Jewgiński M, Krzciuk-Gula J, Makowski M, Latajka R, Kafarski P.

3. Ruthenium-nitrosyl complexes with glycine, L-alanine, L-valine, L-proline, D-proline, L-serine, L-threonine, and L-tyrosine: synthesis, X-ray diffraction structures, spectroscopic and electrochemical properties, and antiproliferative activity. [Inorg Chem. 2014 Mar 3] Author: Rathgeb A, Böhm A, Novak MS, Gavriluta A, Dömötör O, Tommasino JB, Enyedy EA, Shova S, Meier S, Jakupec MA, Luneau D, Arion VB.

4. Application of a genetically encoded biosensor for live cell imaging of L-valine production in pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum strains. [PLoS One. 2014 Jan 17] Author: Mustafi N, Grünberger A, Mahr R, Helfrich S, Nöh K, Blombach B, Kohlheyer D, Frunzke J.

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