Tricalcium Phosphate Side Effects

Tricalcium Phosphate (Food Grade) E341 (iii) appears as a white odorless powder. It is used as an anti-caking agent, nutritional supplement (calcium intensifier), pH regulator and buffer. This product is often used in flour, additives in milk powder, candy, pudding, condiments, and meat products. Though it’s considered safe, some are convinced it has potentially dangerous health effects.

What Is Tricalcium Phosphate E341 (iii)?

Tricalcium Phosphate E341 (iii) is a food additive made from a calcium salt of phosphoric acid. Tricalcium Phosphate is frequently used in the food industry as an additive in powdered spices, and acts as an anti-caking agent. It is sometimes used as a rising agent. It adds smoothness and opacity to reduced fat liquids and foods. It is used to increase calcium levels in dairy products and in juice. Tricalcium Phosphate E341 (iii) is used in candy, wine, beverages, cheese, and jams.

Possible Side Effects of Tricalcium Phosphate E341 (iii)

Tricalcium Phosphate E341 (iii) is generally considered a safe ingredient. The side effects may

  • nausea or vomiting;
  • decreased appetite;
  • constipation;
  • dry mouth or increased thirst; or.
  • increased urination.

GRAS Affirmation: Yes

Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Tricalcium Phosphate E341 (iii) is considered safe by FDA.

Suggested Dosage


Special Populations Precaution

There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Hydrolyzed Pork Collagen populations. Better consult to your doctor if you would like to intake Tricalcium Phosphate E341 (iii).



Related Research

1. Tailor-made tricalcium phosphate bone implant directly fabricated by a three-dimensional ink-jet printer. [J Artif Organs. 2006] Author: Igawa K, Mochizuki M, Sugimori O, Shimizu K, Yamazawa K, Kawaguchi H, Nakamura K, Takato T, Nishimura R, Suzuki S, Anzai M, Chung UI, Sasaki N.

2. The bacterial inhibitory ability and in vivo drug release pattern of a new drug delivery system: ciprofloxacine/tricalcium phosphate delivery capsule. [J Tongji Med Univ. 1998] Author: Zheng Q, Wu H, Du J, Li S, Yan Y.

3. Granular tricalcium phosphate grafting of cavitary lesions in human bone. [Clin Orthop Relat Res. 1994 Sep] Author: Nicholas RW, Lange TA.