Type 2 Collagen is the signature structural protein of hyaline cartilage, articular cartilage, and intervertebral discs, representing 80–90% of cartilage collagen content. Two functionally distinct commercial forms exist: (1) Native/Undenatured Type II Collagen (UC-II-style) retains the triple-helical structure and functions through oral tolerance mechanism — low doses (40 mg/day) train the immune system to stop attacking native joint collagen. This reduces autoimmune-driven joint inflammation.
Clinical research demonstrates superior efficacy vs glucosamine+chondroitin at much lower doses. (2) Hydrolyzed Type II Collagen provides cartilage-specific amino acids and bioactive peptides for structural repair at 1–5 g/day doses. Production: chicken sternum → gentle enzymatic or pH-controlled extraction to preserve native structure → low-temperature processing → spray or freeze-drying. Meets FDA GRAS, EU Novel Food, and ISO 22000 standards.