Applications and Uses of Natamycin

Natamycin E235 can be used in Food, Beverage, Pharmaceutical, Health & Personal care products, Agriculture/Animal Feed/Poultry. Natamycin E235 is used as food preservative in cheese, fermented meat, yogurt, beverages, wines and baked goods against yeasts and molds. Natamycin E235 has no effect on bacteria, so it does not prevent in the natural maturing process of food.

Natamycin E235 is a white to yellow flavourless, odourless crystalline powder. It is very stable with its crystal form. The solubility of Natamycin E235 is very low in water and in most organic solvents. Only 50mg Natamycin E235 can be dissolved in pure water at room temperature. The low solubility makes it very suitable for use on the surface of food. Natamycin E235 will stay on surface of food, where most moulds and yeasts may grow, but does not influence the natural course of fermentation inside.

Natamycin E235 (Pimaricin) is an antimycotic product which have broad and effective action. It not only used to inhibit the growth of different moulds and yeasts, but also inhibits the production of their toxin. Commercial Natamycin E235 contains 50% of the active substance. Small quantities of Natamycin E235 can inhibit all moulds and yeasts, which cause food spoilage. Natamycin E235 has no effect on bacteria, so it does not prevent in the natural maturing process of yoghurt , cheese , fresh Ham, sausage, etc.

Natamycin E235 is polyene macrolide anti mycotic. But it is very sensible to oxidation and ultraviolet radiation. Natamycin E235 can hinder almost all the fungi (moulds and yeasts), but could not result in bacteria, virus or other microorganism. Many factors can influence the stability of Natamycin E235 when in use, like acidity (PH value), temperature, light, oxygen, heavy metal, etc.

Natamycin E235 uses as follows:

In Food Production

Natamycin E235 has a long history of safe use as a natural mold inhibitor in cheese, meat, used as preservative in food production.

Ideal result can be achieved by using Natamycin E235 on the exposed surface of the food where the moulds and yeasts may grow. This is especially useful for cheese manufacturing, since the mould growth is prevented, while the cheese ripening bacteria will grow and metabolize normally.

Application standard:
1. U.S.A.: FDA, § 172. 155, 2000: Treat (Spray or dip) the surface of the cheese with 200-300mg/kg aqueous solutions.
2. EU: Permitted on the surface of cheese and sausage casings
3. China: GB2760-2001: used in cheese, meat and meat products, moon cakes, snacks, raw juice for coating use, surface of utensils, perishable food, Salad sauce, Fermented wine, etc.
The FAO/WHO Joint Expert Committee on Food Additive confirmed the acceptable daily intake (ADI) if Natamycin as 0.3mg/KG (total body weight). This was also endorsed by the EU. In China its use is permitted in the food industry.



Max use(g/kg)

Application and use


Natamycin and Lactose

0.3 g/kg

cottage cheese

0.3 g/kg


0.3 g/kg

Sauce stew meat products category

0.3 g/kg

Smoked, roasted, roasted meat

0.3 g/kg

Fried meat

0.3 g/kg

Western Ham (smoked, smoked, steamed ham) category

0.3 g/kg

Meat enema

0.3 g/kg

Fermented meat products category

0.02 g/kg

Mayonnaise, salad dressing

0.3 g/kg

Fruit and vegetable juices (pulp

0.01 g/L

Fermented wine



Natamycin E235 is a naturally occurring anti-fungal agent produced during fermentation of bacterium Streptomyces natalensis.

In Beverage

Natamycin E235 can be used as preservative in beverage.

In Pharmaceutical

Natamycin E235 can be used as a topical treatment like eye drops.

In Health and Personal care

Natamycin E235 can be used as preservative in Cosmetics.

In Agriculture/Animal Feed/Poultry

Natamycin E235 can be used as preservative in Agriculture/Animal Feed/Poultry feed.

In Other Industries

Natamycin E235 is also used to protect crops from spoiling.