Butylated hydroxytoluene (BHT) E321, also known as dibutylhydroxytoluene, used as an antioxidant in food, cosmetics, pharmaceuticals. Though it’s considered safe, some are convinced it has potentially dangerous health effects.
What Is Butylated hydroxytoluene E321?
Butylated Hydroxy Toluene E321 appears as a white crystalline powder. It is a food grade antioxidant that can stabilize a variety of organic materials against oxidative deterioration and is particularly useful in preventing fats and fat containing foods from becoming rancid. It is a particularly good antioxidant for stabilizing meat, fish, and bone meals
Possible Side Effects of Butylated hydroxytoluene E321
Although Butylated hydroxytoluene E321 generally regarded as a very safe and effective supplement, there can be some minor side effects. The side effects may:
Possible short-term side effects
Possible long-term side effects
- numerous types of cancer
- liver lesions
- tumor production
- biochemical changes
- cell mutation
- endocrine disruption
- fetal cell toxicity
GRAS Affirmation: Yes
Generally recognized as safe (GRAS) is an American Food and Drug Administration (FDA) designation that a chemical or substance added to food is considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Butylated hydroxytoluene E321 is considered safe.
Special Populations Precaution
There is a lot of concern about diet and nutrition for these population, like Newborns, children, pregnant, sensitive to Butylated hydroxytoluene E321 populations. Better consult to your doctor if you would like to intake Butylated hydroxytoluene E321.
1. FT-IR, FT-Raman spectra, density functional computations of the vibrational spectra and molecular geometry of butylated hydroxy toluene. [Spectrochim Acta A Mol Biomol Spectrosc. 2011 Aug] Author: Babu PC, Sundaraganesan N, Dereli Ö, Türkkan E.
2. Effect of a polyherbal formulation, Ambrex, on butylated hydroxy toluene (BHT) induced toxicity in rats. [Indian J Exp Biol. 2003 Nov] Author: Devi RS, Narayan S, Mohan KV, Sabitha KE, Devi CS.
3. Induction of type 1 programmed cell death in U937 cells by the antioxidant, butylated hydroxy-toluene or the free radical spin trap, NTBN. [Leuk Res. 1999 Jul] Author: Anderson KM, Ou D, Wu YB, Jajeh A, Harris JE.
4. Pulmonary phospholipid changes induced by butylated hydroxy toluene, an antioxidant, in rats. [Indian J Exp Biol. 1995 Oct] Author: Tamizhselvi R, Samikkannu T, Niranjali S.
5. Allopurinol promotes and butylated hydroxy toluene prevents sugar-induced cataractogenesis. [Biochem Biophys Res Commun. 1990 May 16] Author: Ansari NH, Srivastava SK.