Natamycin, còn được gọi là pimaricin, is a naturally derived antifungal compound được sản xuất bởi the aerobic fermentation of Streptomyces natalensis. It belongs to the polyene macrolide class of antimicrobials and works by binding specifically to ergosterol in fungal cell membranes. This disrupts membrane integrity and prevents fungal growth. Natamycin has no effect on bacteria. Điều này khiến nó lý tưởng cho ứng dụng where beneficial bacterial cultures must remain active.
The compound is effective ở nồng độ rất thấp, typically 1-20 ppm on food surfaces. It được sử dụng rộng rãi in the dairy and meat industries as a surface treatment to prevent mold contamination during bảo quản and ripening. Natamycin is approved for food use in over 40 countries and is recognized as a safe and effective natural chất bảo quản by international food safety authorities.